You do not need to avoid grapefruit if you're taking dipyridamole or low-dose aspirin.Ĭiclosporin, sirolimus and tacrolimus are medicines that moderate your immune system (the body's natural defence system). If you're taking ticagrelor, grapefruit may increase the effects of your medicine and make you bleed more easily. They help to prevent heart attacks and strokes.ĭo not drink grapefruit juice if you're taking the antiplatelet medicine clopidogrel, as it may mean your medicine works less effectively. It's safer to drink grapefruit juice if you're taking the newer anticoagulants rivaroxaban, dabigatran, apixaban or edoxaban.Īntiplatelet medicines prevent platelets (a type of blood cell) from sticking together and forming blood clots. It can increase the effect of warfarin on your blood, making you bleed more easily. They're given to people at high risk of getting clots, to reduce their chances of serious conditions such as strokes and heart attacks.ĭo not drink grapefruit juice if you're taking warfarin. Grapefruit juice is not the only food/drink that can cause these problems, but it's certainly one of the more notable ones.Īnticoagulants are medicines that help to prevent blood clots. Disrupt those, and you end up with not enough drug. In these cases, the grapefruit juice is affecting proteins which transport the drug into your bloodstream. Weirdly enough, there are some other drugs where grapefruit juice has the opposite effect for other reasons. the range where they start having too many negative effects, and even if they don't, your doctor needs to know how much you are actually getting so they can adjust your dosage. For mental health medication, this is a REALLY big problem - these drugs tend to have a narrow effective range vs. Since the dosage is made assuming the enzyme will block some of it and it no longer does, you end up with a far higher dose than intended. The problem is that grapefruit juice interacts with the enzyme, and if its tying up all the enzyme when you take a pill, it can't intercept part of the medicine. One of the ways it does this is with the use of certain enzymes. Medications are dosed assuming a certain percentage of them flat out won't work - your body will process some of them and kick them out prior to them entering the bloodstream.
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